Played Markie Post's daughter in the horror film I've Been Waiting for You (1998) (TV) and Post also plays her mom as a guest star on Sarah's sitcom, "Scrubs" (2001).

At times on the set of "Scrubs" (2001), Sarah is referred to as "Second Becky" in response to her being the second "Becky" on "Roseanne" (1988).

Sarah grew up in Vancouver, British Columbia.

Attended the 1999 CCMA award ceremony, and presented an award for the best single of the year. [13 September 1999]

She has a brown Labrador named Lola, which the "Scrubs" (2001) cast bought her at a charity auction.

Engaged to entertainment lawyer Jaime Afifi. [December 2006]

She volunteers at a hospice for terminally ill children and works for the Audrey Hepburn Children's Fund.

She is vegetarian. Initially her father was not, but he eventually gave in due to family pressure.

Appeared in local Vancouver theater productions, at age 8.

Her father is a lawyer and both her parents are mediators who also run a child adoption agency. Two years ago, she accompanied her parents to China to coordinate the adoption of several orphans there.

Has an older sister named Natasha.

Took over the role of Becky on "Roseanne" (1988) from Alicia Goranson in 1993.

Close friend with actresses Christa Miller and Nicole Sullivan.

She has dogs named Harley and Tankers.

Said she would like to take a break from acting and attend college. [2001]

She shares her birthday with actresses Alexa Vega and Chandra Wilson.

In her leisure time, Chalke prefers cooking with friends (especially Thai and sushi), playing the guitar, hiking, skiing (she's an instructor), snowboarding, kayaking and reading.

Has a younger sister named Piper.

When she was a few credits short of a college degree, she decided to commit to acting full time.

Is fluent in French and German.

Her first on-camera kiss was in the 1992 movie City Boy (1992) (TV), shot at Lighthouse Park in Vancouver.

Close friend with "Scrubs" (2001) co-star Zach Braff.

Played older sister of Sara Gilbert on "Roseanne" (1988), but is younger in real life. [1993-1997]