Was approached to play the role of Becky in Clerks II (2006), but turned it down because she had just finished the pilot for "Grey's Anatomy" (2005).

She's engaged to music producer Christopher Ivery.

Had another scene in Daredevil (2003) as Matt Murdock's (Ben Affleck) secretary Karen Page, but it was deleted from the theatrical version of the film.

Is a native of Boston.

She is the youngest of 6 - she has 5 siblings who are all at least 8 years older than her. One of them is Maureen Pompeo.

Had a part in Eternal Sunshine of the Spotless Mind (2004), which was deleted from the final cut.

Her mother died when she was only 4 years old. Her father is Joseph Pompeo, a salesman.

Suffers from asthma.

Before "Grey's Anatomy" (2005), she auditioned for a television pilot called "Secret Service". That show was not picked up by any television network.

Engaged to music producer Chris Ivery [November 13, 2006]. After they started dating three years ago, they learned that they both grew up in Boston, 10 miles from each other.

Wed fiancé Christopher Ivery in a civil ceremony in New York City on November 9, 2007. The only people in attendance were Mayor Michael Bloomberg and First Deputy Mayor Patti Harris, who served as witnesses to the ceremony.