Father of twins, daughter Kaya and son Dade Faison (b. 1999) and son Kobe Faison (b. 2001) with ex-wife Lisa Askey. Has a son named Sean Faison-Ince (b. 1996) from a previous relationship with Audrey Ince.
His "Scrubs" (2001) co-stars refer to him as "that guy from Clueless (1995)." Similarly, cast-mate Sarah Chalke is called "Becky Number Two," in reference to her role on "Roseanne" (1988)".